Isaac Guerendo is expected to replace Christian McCaffrey and Jordan Mason on injured reserve as the 49ers’ starting running back
Isaac Guerendo is expected to step in as the San Francisco 49ers’ starting running back after injuries to Christian McCaffrey and Jordan Mason. Guerendo, a versatile fourth-round rookie from Louisville, has shown impressive speed, averaging 5.9 yards per carry with 246 yards and two touchdowns on 42 rushes.